Treatment and nutritional management of cancer cachexia: a systematic review
DOI:
https://doi.org/10.55892/jrg.v8i18.1959Keywords:
cancer cachexia, nutrition, therapeutics, management e intervention.Abstract
Cancer cachexia is a multifactorial syndrome characterized by the continuous loss of skeletal muscle mass, which may or may not be accompanied by loss of adipose mass and which cannot be completely reversed with nutritional support. Nutritional intervention has a great importance in the treatment of cancer cachexia, however, there is still low evidence when it comes to specific interventions. The present review aims to analyze forms of treatment and nutritional management of cancer cachexia available in the literature, synthesize the results of original studies on nutritional treatment for cancer cachexia and describe the outcomes related to quality of life, survival, nutritional status, laboratory tests, functional capacity and adverse effects related to nutritional therapy. This is a systematic literature review study, which brought together the results of original studies on nutritional treatment for cancer cachexia in adult patients over the last 10 years, using Pubmed as a database. The PICO strategy was used to formulate the research question. Seven original articles that address the question of this review were analyzed. The heterogeneity of available studies was observed, such as variation in study design, sample, types of nutritional intervention, feeding routes (oral, enteral and parenteral) and outcomes, which made it difficult to compare the analyzed results. In conclusion, nutrition plays a fundamental role in the management of cancer cachexia, being able to improve quality of life, muscle mass, strengthening the immune system, and improving the clinical condition. However, more studies would be needed to elucidate such nutritional strategies and make recommendations for clinical practice.
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